Ketogenic diets have been used to treat epilepsy for nearly a century. When traditional therapies fail-typically pharmacology with anti-seizure drugs-this metabolic approach is often effective. Proven and dramatic success in stopping seizures has led to an interest in metabolic therapies for targeting overall physiology and signaling pathways and restoring brain homeostasis. Ketogenic Diet and Metabolic Therapies: Expanded Roles in Health and Disease is a comprehensive scientific resource, covering the latest research on cellular and molecular mechanisms, established and emerging applications, metabolic alternatives, and implications for general health and disease prevention and treatment. Experts share research spanning ion channels to epigenetics, insights based on decades of experience in epilepsy, and evidence for emerging applications such as autism spectrum disease, Alzheimer disease, and malignant brain cancer. Research into metabolism-based treatments has spread to laboratories and clinics involving diverse discipline, yielding new classes of drugs, medical foods, and therapeutic regimes. The book's senior editor, Susan Masino, brings her unique expertise and perspective to the overall scope of this one-of-a-kind work. Additional leaders enhance its breadth and quality: section editors Detlev Boison, Dominic D'Agostino Eric Kossoff, and Jong Rholend oversight on major subdivisions. Book jacket.